Alclometasone
CAS No. : 67452-97-5
(Synonyms: 7a-Chloro-16a-methyl prednisolone)
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| Cat. No. : | HY-A0150 |
| M.Wt: | 408.92 |
| Formula: | C22H29ClO5 |
| Purity: | >98 % |
| Solubility: | 10 mM in DMSO |
Alclometasone (7a-Chloro-16a-methyl prednisolone) is a glucocorticoid and inhibits the release of pro-inflammatory mediators from leukocytes. Alclometasone can be used to relieve corticosteroid-responsive dermatoses, including atopic?dermatitis, eczema, psoriasis and allergic dermatitis[1]. IC50 & Target: IC50: glucocorticoid receptor[1] In Vivo: The prodrug of alclometasone is alclometasone dipropionate[2].Alclometasone dipropionate (subcutaneous injection; 1 % (w/v) arabic gum; 2 weeks) inhibits the activity of androgen-dependent cytochrome P450 and O-depropylation activity as a dose-dependent manner in male Slc-Wistar strain rats. However, it has no effects on hepatic drug metabolism in female rats or DS strain mice[2].
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