Isorhamnetin 3-O-galactoside
CAS No. : 6743-92-6
(Synonyms: Cacticin)
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| 5mg | $320 | In-stock |
| 10mg | $520 | In-stock |
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| Cat. No. : | HY-N2082 |
| M.Wt: | 478.40 |
| Formula: | C22H22O12 |
| Purity: | >98 % |
| Solubility: | DMSO : 100 mg/mL (ultrasonic) |
Isorhamnetin 3-O-galactoside (Cacticin) is a flavonoid glycoside that can be isolated from Oenanthe javanica, with antithrombotic and profibrinolytic activities. Isorhamnetin 3-O-galactoside inhibits the activities of thrombin and factor Xa (FXa) and reduces thrombin-catalyzed fibrin polymerization maximum rate. Isorhamnetin 3-O-galactoside suppresses TNF-α-induced PAI-1 secretion, decreases the PAI-1/tissue-type plasminogen activator (t-PA) ratio, and inhibits FXa production and FVa/FXa-mediated thrombin generation. Isorhamnetin 3-O-galactoside exerts protective effects against Carbon tetrachloride (CCl4) (HY-Y0298)-induced hepatic injury in mice. Isorhamnetin 3-O-galactoside can be used for the study of liver injury-related diseases and thrombotic vascular diseases[1][2][3].
In Vitro:Isorhamnetin 3-O-galactoside (0.5-50 μM) inhibits TNF-α/FVIIa-mediated thrombin and FXa production in HUVECs[2].
Isorhamnetin 3-O-galactoside (0.5-50 μM, 18 h) dose-dependently inhibits TNF-α-induced PAI-1 secretion in HUVECs[2].
Isorhamnetin 3-O-galactoside (1-5 μM, 6 h) potently inhibits LPS (100 ng/ml, 16 h)-induced HMGB1 release in HUVECs[3].
Isorhamnetin 3-O-galactoside (1-5 μM, 6 h) decreases LPS- or HMGB1-induced barrier disruption [3].
Isorhamnetin 3-O-galactoside (5 μM, 6 h) inhibits HMGB1-induced paracellular gap formation in HUVECs and promotes the formation of dense F-actin rings, maintaining the morphological integrity of endothelial cells[3].
Isorhamnetin 3-O-galactoside (1-5 μM, 6 h) suppresses HMGB1-induced expression of vascular cell adhesion molecule-1 (VCAM-1) in HUVECs[3].
Isorhamnetin-3-O-galactoside (1-5 μM, 6 h) significantly suppresses HMGB1-induced activation of Phospho-NF-κB p65 and TNF-α in HUVEC nuclear lysates[3].
In Vivo:Isorhamnetin 3-O-galactoside (50-200 mg/kg, i.p., twice: 30 min before and 2 h after CCl4 injection) attenuates CCl4-induced hepatic injury in male ICR mice[1].
Isorhamnetin 3-O-galactoside (2.4 mg/kg, intravenous administration, once) significantly prolongs the tail bleeding time[2].
Isorhamnetin 3-O-galactoside (4.8 mg/mouse, i.v., once) markedly inhibits HMGB1 release in cecal ligation and puncture (CLP)-induced septic male C57BL/6 mice[3].
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