DL-Mevalonolactone

DL-Mevalonolactone ((±)-Mevalonolactone;Mevalolactone) is the δ-lactone form of mevalonic acid, a precursor in the mevalonate pathway. DL-Mevalonolactone is orally active against HMGCR mutation and statin caused myopathy^[3]. DL-Mevalonolactone induces inflammation and oxidative stress response with decreased mitochondrial membrane potential (MMP) and induces mitochondrial swelling^[2][4]. In Vitro:DL-Mevalonolactone (0.1-1 mM, 0-72 h) induces inflammatory response with upregulated IL1B expression,induces oxidative stress with mitochondrial membrane depolarization and increased levels of SOD2, HemeOX and ROS^[4]. DL-Mevalonolactone(1-2 mM) promotes peroxidation, inhibits activity of aconitase in brain^[2]. In Vivo:DL-Mevalonolactone exhibits efficacy against statin induced myopathy in C57BL/6 mice (200 mg/kg, p.o. for 14 days), without toxicity (2 g/kg, p.o. for 7 days)^[3].