Drospirenone
CAS No. : 67392-87-4
(Synonyms: Dihydrospirorenone)
| Size | Price | Stock |
|---|---|---|
| 5mg | $35 | In-stock |
| 10mg | $55 | In-stock |
| 50mg | $165 | In-stock |
| 100mg | $264 | In-stock |
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| Cat. No. : | HY-B0111 |
| M.Wt: | 366.49 |
| Formula: | C24H30O3 |
| Purity: | >98 % |
| Solubility: | DMSO : 50 mg/mL (ultrasonic) |
Drospirenone (Dihydrospirorenone) is an orally active fourth-generation progestin that interacts with the progesterone receptor (PR) and androgen receptor (AR). Drospirenone significantly decreases both plasminogen activator inhibitor-1 (PAI-1) and tissue plasminogen activator (tPA) via the AR. Drospirenone can produce DNA damage in bone marrow cells of female mice. [1][2][3][4].
In Vitro: Drospirenone (10-150 µM, 24-48 h) has the value of EC50 (105 to 119 μM (24 h exposure) and 51 to 58 μM (48 h exposure)) for the cytotoxicity in PLHC-1 cells[1].
Drospirenone (10-200 µM, 15-120 min) increases ROS production in PLHC-1 cells[2].
Drospirenone (0.01-10 µM, 24 h) decreases both PAI-1 and tPA secretion in human immortalized endometrial endothelial cells (HEEC)[2].
Drospirenone (1-100 µM, 72 h) causes DNA damage to MCF-7 cells when supplemented with mice liver S9 fraction[3].
In Vivo: Drospirenone (10-100 mg/kg, oral gavage for five days) caused DNA damage in bone marrow cells of adult female mice[3].
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