Hexa-D-arginine
CAS No. : 673202-67-0
(Synonyms: Furin Inhibitor II)
| Size | Price | Stock |
|---|---|---|
| 1mg | $70 | In-stock |
| 5mg | $200 | In-stock |
| 10mg | $320 | In-stock |
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| Cat. No. : | HY-P1028 |
| M.Wt: | 954.14 |
| Formula: | C36H75N25O6 |
| Purity: | >98 % |
| Solubility: | H2O : 50 mg/mL (ultrasonic);DMSO : 5 mg/mL (ultrasonic) |
Hexa-D-arginine (Furin Inhibitor II) is a stable furin inhibitor with Ki values 106 nM, 580 nM and 13.2 μM for furin, PACE4 and prohormone convertase-1 (PC1), respectively. Hexa-D-arginine blocks Pseudomonas exotoxin A and anthrax toxins toxicity in vitro and in vivo[1][2][3]. IC50 & Target:Ki: 106 nM (Furin), 580 nM (PACE4) and 13.2 μM (PC1)[3] In Vitro: Hexa-D-arginine effectively blocks Pseudomonas aeruginosa exotoxin A (PEA)-induced cell lysis and is itself noncytotoxic[1]. In Vivo: Administration of Hexa-D-arginine (0.1, 1, or 10 nM) to Pseudomonas aeruginosa exotoxin A (PEA)-treated mice (6-week-old FVB and 129/Sv mice) significantly improves their survival rate and also decreases circulating levels of TNF-α[1].
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