Fluocinolone (Acetonide)
CAS No. : 67-73-2
| Size | Price | Stock |
|---|---|---|
| 500mg | $77 | In-stock |
| 1g | $132 | In-stock |
| 5g | $462 | In-stock |
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| Cat. No. : | HY-B0415 |
| M.Wt: | 452.49 |
| Formula: | C24H30F2O6 |
| Purity: | >98 % |
| Solubility: | DMSO : ≥ 31 mg/mL |
Fluocinolone is a glucocorticoid glucocorticoid receptor agonist. Fluocinolone is effective in preventing both lipid accumulation and inflammation. Fluocinolone can promote the proliferation of DPCs and has the potential role in repairing injured pulp tissues. Fluocinolone can be used to study the prevention of chemotherapy-induced peripheral neuropathy caused by Paclitaxel (HY-B0015)[1][2][3][4].
In Vitro: Fluocinolone (0.1-50 μg/mL, 2 days) improves foam cell survival in THP-1 cells[1].
Fluocinolone (0.1-50 μg/mL, 2 days) inhibits infammatory cytokines secretion and reduces cholesteryl ester accumulation[1].
Fluocinolone (0.1-100 μmol/L, 24 h) promotes the proliferation of DPCs[2].
Fluocinolone (1-10 μmol/L, 7 days) promotes the expressions of BSP, OCN, DSPP, and Wnt4, and up-regulates Wnt4 and the dentin-specific marker dentin sialophosphoprotein[2].
In Vivo: Fluocinolone (500 μg/kg, Intraperitoneal injection, once a day for 2 weeks) prevents development of significant peripheral neuropathy in a mouse model of PTX-induced[3].
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