EGTA
CAS No. : 67-42-5
| Size | Price | Stock |
|---|---|---|
| 25g | $19 | In-stock |
| 100g | $67 | In-stock |
| 500g | $163 | In-stock |
| 1000g | $313 | In-stock |
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| Cat. No. : | HY-D0861 |
| M.Wt: | 380.35 |
| Formula: | C14H24N2O10 |
| Purity: | >98 % |
| Solubility: | 1 M NaOH : ≥ 100 mg/mL;H2O : 4.76 mg/mL (ultrasonic;warming;adjust pH to 9 with 1 M NaOH;heat to 60°C);DMSO : < 1 mg/mL (ultrasonic) |
EGTA is a cell-impermeant specific calcium ion chelator. EGTA has an apparent calcium dissociation constant (Kd) of 60.5 nM at physiological pH (7.4) and has very high specificity for Ca2+ over Mg2+ (Mg2+ Kd 1-10 mM). EGTA significantly inhibits the substrate adherence capacity of inflammatory macrophages[1][2]. In Vitro:EGTA, proposed as endodontic irrigant, decreases substrate adherence capacity of inflammatory macrophages in a time- and dose-dependent manner. The EGTA concentration that causes an IC50 is 202 mM. Chelators react with calcium ions in the hydroxyapatite crystals to produce a metallic chelate. Removal of calcium ions from the dentine makes the dentinal tissue softer, especially the hydroxyapatite-rich peritubular dentin and increases the diameter of exposed dentinal tubules[2].
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