Thiamine disulfide
CAS No. : 67-16-3
| Size | Price | Stock |
|---|---|---|
| 500mg | $50 | In-stock |
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| Cat. No. : | HY-B2224 |
| M.Wt: | 562.71 |
| Formula: | C24H34N8O4S2 |
| Purity: | >98 % |
| Solubility: | DMSO : 250 mg/mL (ultrasonic) |
Thiamine disulfide, a vitamin B1 derivative, is an oxidized dimer of Thiamine. Thiamine disulfide is a potent HIV-1 inhibitor. Thiamine disulfide significantly depresses HIV-1 transactivator (Tat) activity[1][2]. In Vitro: Thiamine disulfide markedly inhibits production of progeny HIV-1 in acute and chronic HIV-1-infected CEM at nontoxic concentrations of 500-1000 μM. Thiamine disulfide (500 μM) blocks 99.7% of HIV-1 production after 96 hours culture in acute HIV-1 (LAV-1) infection, whereas it inhibits 90-98% of HIV-1 production in chronic-infected cells (CEM/LAV-1, H9/MN, and Molt-4/IIIB)[1].
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