VQW-765
CAS No. : 669770-29-0
(Synonyms: AQW-051)
| Size | Price | Stock |
|---|---|---|
| 5mg | $80 | In-stock |
| 10mg | $130 | In-stock |
| 25mg | $280 | In-stock |
| 50mg | $420 | In-stock |
| 100mg | $590 | In-stock |
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| 500 mg | Get quote | |
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| Cat. No. : | HY-19490 |
| M.Wt: | 294.40 |
| Formula: | C19H22N2O |
| Purity: | >98 % |
| Solubility: | DMSO : 16.67 mg/mL (ultrasonic;warming;heat to 60°C) |
VQW-765 (AQW-051) is a selective and orally active alpha-7 nicotinic acetylcholine receptor (α7-nAChR) agonist with a pKD value of 7.56 to recombinantly expressed human α7-nAChR. VQW-765 shows anxiolytic-like effect in vivo. VQW-765 can be used for the research of anxiety disorder and acute performance anxiety[1]. In Vitro: VQW-765 shows a binding efficacy with a pKD value of 7.56 to recombinantly expressed human α7-nACh receptor[1]. VQW-765 shows a potent agonist activity to calcium transients that detected after stimulation of human α7-nACh receptors recombinantly expressed in GH3-ha7-22 cells with a pEC50 value of 7.41[1]. In Vivo: VQW-765 (0.03 and 0.3 mg/kg; oral administration once) increases cognitive effect and learning/memory performance in mice[1]. VQW-765 (1 mg/kg; oral administration once) shows anxiolytic-like effect with increasing the social exploration time in rats with a duration of at least 6 h[1].
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