Talniflumate
CAS No. : 66898-62-2
(Synonyms: BA 7602-06)
| Size | Price | Stock |
|---|---|---|
| 5mg | $50 | In-stock |
| 10mg | $80 | In-stock |
| 25mg | $165 | In-stock |
| 50mg | $265 | In-stock |
| 100mg | $420 | In-stock |
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| Cat. No. : | HY-103370 |
| M.Wt: | 414.33 |
| Formula: | C21H13F3N2O4 |
| Purity: | >98 % |
| Solubility: | DMSO : 62.5 mg/mL (ultrasonic;warming;heat to 60°C) |
Talniflumate (BA 7602-06) is the prodrug of Niflumic acid (HY-B0493), exerting its activity in the body through conversion to niflumic acid by esterase[1]. Talniflumate is an orally active Ca2+-activated Cl- channel (CaCC) blocker. Talniflumate can be used as an analgesic and anti-inflammatory agent in cystic fibrosis mouse model of distal intestinal obstructive syndrome[2]. IC50 & Target: IC50: Ca2+-activated Cl- channel (CaCC)[1] In Vivo: Talniflumate (oral chow; 0.4 mg/g; 21 days) significantly increases CF mouse survival from 26 to 77%. It does not alter crypt goblet cell numbers or change intestinal expression of mCLCA3 but tends to decrease crypt mucoid impaction[1].
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