Practolol
CAS No. : 6673-35-4
| Size | Price | Stock |
|---|---|---|
| 5mg | $43 | In-stock |
| 10mg | $70 | In-stock |
| 25mg | $120 | In-stock |
| 50mg | $200 | In-stock |
| 100mg | $300 | In-stock |
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| 500 mg | Get quote | |
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| Cat. No. : | HY-119802 |
| M.Wt: | 266.34 |
| Formula: | C14H22N2O3 |
| Purity: | >98 % |
| Solubility: | DMSO : 100 mg/mL (ultrasonic) |
Practolol is a potent and selective β1-adrenergic receptor antagonist. Practolol can be used for the research of cardiac arrhythmias[1][2][3].
IC50 & Target: β1-adrenergic receptor[1]
In Vitro: Practolol (10 μM; 30 min) preferentially antagonizes the relaxant effects produced by R0363 in spontaneously contracted tracheal preparations from the guinea-pig[1].
Practolol (10 nM-100 μM) blocks the progesterone production induced by (-)epinephrine in a dose-dependent manner in granulosa cells[2].
In Vivo: Practolol (0.5 mg/kg; i.v.) decreases heart rate, left ventricular dP/dt max, myocardial blood flow and cardiac output in intact close-chest dogs[3].
Practolol (0.5 mg/kg; i.v.) decreases normal myocardial blood flow but flow in the ischaemic area remains unchanged after coronary artery ligation[3].
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