Apraclonidine
CAS No. : 66711-21-5
(Synonyms: ALO 2145 (free base))
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| Cat. No. : | HY-12720 |
| M.Wt: | 245.11 |
| Formula: | C9H10Cl2N4 |
| Purity: | >98 % |
| Solubility: | 10 mM in DMSO |
Apraclonidine (ALO 2145 (free base)), a selective α2 and weak α1 receptor agonist activity, effectively low intraocular pressure (IOP) in human eyes. Apraclonidine hydrochloride is a topical ophthalmic solution[1][2]. In Vitro: Apraclonidine (ALO 2145 (free base)) is more commonly used topically for glaucoma, as it penetrates the cornea and blood-brain barrier to a lesser extent and, thus, has fewer adverse systemic effects[2]. In Vivo: Apraclonidine (ALO 2145 (free base)) is effective in animal models of elevated IOP as well as glaucoma in humans. The ocular hypotensive effects of Apraclonidine are usually attributed to reduced aqueous humor synthesis and vasoconstrictor actions at the anterior segment branches of the ophthalmic artery. Apraclonidine (ALO 2145 (free base)) (1.15%, single instillation) inhibits 98% of PGE2-induced aqueous flare elevationy[2][3].
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Inquiry Information- Product Name:
- Apraclonidine
- Cat. No.:
- HY-12720
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