7-Hydroxyflavone

7-Hydroxyflavone is a flavonoid isolated from Clerodendrum phlomidis, with anti-inflammatory activity. 7-Hydroxyflavone protects renal cells from nicotine (NIC)-associated cytotoxicity via the ERK/Nrf2/HO-1 pathway. 7-Hydroxyflavone inhibits PKM2 with an IC₅₀ of 2.12 μM. 7-Hydroxyflavone inhibits COX-2 and 5-LOX with IC₅₀ of 27 µg/mL and 33 µg/mL. 7-Hydroxyflavone is orally active^[1][2][4]. In Vitro:7-Hydroxyflavone (20 μM, 24 h) inhibits nicotine-induced cytotoxicity, reduces nicotine-induced ROS production, and exhibits antioxidant activity in rat renal proximal tubule cells NRK52E^[2].
7-Hydroxyflavone (50 μM, 24 h) inhibits EV71 3C protease, blocks the viral replication, and inhibits the proliferation of enterovirus 71 (EV71) with an EC₅₀ of 19.95 μM^[3].
7-Hydroxyflavone (50 μM, 24 h) decreases malondialdehyde (MDA) and ROS levels, increases SOD and GSH levels, increases mitochondrial DNA content and ATP levels in HepG2 cells^[7]. In Vivo:7-Hydroxyflavone (5-20 mg/kg, ip, once a day for 7 days) inhibits inflammatory cytokines, reduces myocardial injury markers (such as c-TnI, CK, LDH, and AST), inhibits apoptosis, alleviates oxidative stress, and ameliorates ischemia/reperfusion injury in rats models through MAPK/NF-κB signaling pathway^[5].
7-Hydroxyflavone (5-20 mg/kg, ip, once a day for 7-10 days) ameliorates Paclitaxel (HY-B0015) or Vinorelbine (HY-12053)-induced neuropathic pain in mice model^[6].
7-Hydroxyflavone (50-100 mg/kg, po, once a day for 15 weeks) reduces fat accumulation, improves hepatic steatosis and oxidative stress, regulates blood glucose metabolism, and promotes energy metabolism in mouse NAFLD models^[7].