6-Hydroxyflavone

6-Hydroxyflavone is an orally effective flavonoid compound. 6-Hydroxyflavone can inhibit LPS (HY-D1056) -induced NO production and has anti-inflammatory effects. 6-Hydroxyflavone promotes osteoblast differentiation by activating AKT, ERK 1/2 and JNK signaling pathways. 6-Hydroxyflavone has an inhibitory effect on bovine hemoglobin (BHb) glycosylation. 6-Hydroxyflavone has a kidney protective effect. In addition, 6-Hydroxyflavone enhances GABA-induced current through the Benzodiazepine sites of γ-aminobutyric acid (GABA_A) receptors. 6-Hydroxyflavone shows a clear preference for α2 - and α3 - subtypes, which play an anti-anxiety role^{[1][2][3][4][5][6]}. In Vitro:6-Hydroxyflavone (0-50 μM; 24 h) has no effect on MC3T3 cell viability^[2].
6-Hydroxyflavone (0-40 μM; 4 days-5 weeks) increases the activity of ALP and increases calcium deposition in MC3T3-E1 cells ^[2].
6-Hydroxyflavone (20 μM; 5-60 min) activates AKT, ERK 1/2 and JNK signaling pathways in MC3T3-E1 cells^[2].
6-Hydroxyflavone (0-200 μM; 48 h) shows high inhibitory activity on LPS (HY-D1056) -induced NO production in HBZY-1 cells (IC₅₀: 1.7 μM)^[3].
6-Hydroxyflavone (10 μM; 10 s) enhances GABA-induced current in cortical neurons through the Benzodiazepine sites of γ-aminobutyric acid (GABA_A) receptors and can be blocked by Flumazenil (HY-B0009), which has a high affinity for α2- and α3- subtype receptors in HEK 293T cells^[4]. In Vivo:6-Hydroxyflavone (6-100 mg/kg; Oral administration; Single dose; 45 minutes before test) has anti-anxiety effect in mouse model^[4].
6-Hydroxyflavone (25-50 mg/kg; Intraperitoneal injection; 15 days) shows protective effect in Cisplatin (HY-17394) -induced nephrotoxicity rat model^[5].