RU 24969 (hemisuccinate)
CAS No. : 66611-27-6
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| Cat. No. : | HY-16688B |
| M.Wt: | 287.34 |
| Formula: | C14H16N2O.1/2C4H6O4 |
| Purity: | >98 % |
| Solubility: | 10 mM in DMSO |
RU 24969 hemisuccinate is a preferential 5-HT1B agonist, with a Ki of 0.38 nM, but also displays appreciable affinity for the 5-HT1A receptor (Ki=2.5 nM), and has low affinity for other receptor sites in the brain. RU 24969 hemisuccinate could decrease fluid consumption and increase forward locomotion[1].
In Vitro: RU 24969 (10 μM) reduces K+-stimulated release of [3H]-5-HT from ratfrontalcortex slices in vitro[2].
In Vivo: RU 24969 (0.03-3.0 mg/kg; s.c.) dose-dependently decreases water consumption in water deprived rats[1].
RU 24969 (0.3-3.0 mg/kg; s.c.) dose-dependently increases forward locomotion[1].
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