Kevetrin (hydrochloride)
CAS No. : 66592-89-0
(Synonyms: 4-Isothioureidobutyronitrile hydrochloride; thioureidobutyronitrile hydrochloride; thioureido butyronitrile hydrochloride)
| Size | Price | Stock |
|---|---|---|
| 5mg | $49 | In-stock |
| 10mg | $77 | In-stock |
| 25mg | $160 | In-stock |
| 50mg | $242 | In-stock |
| 100mg | $407 | In-stock |
| 500mg | $1221 | In-stock |
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| 5 g | Get quote | |
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| Cat. No. : | HY-16271 |
| M.Wt: | 179.67 |
| Formula: | C5H10ClN3S |
| Purity: | >98 % |
| Solubility: | DMSO : ≥ 40 mg/mL;H2O : 100 mg/mL (ultrasonic) |
Kevetrin hydrochloride is a potent activator of p53, induces apoptosis in TP53 wild-type and mutant acute myeloid leukemia cells. Kevetrin a preferential cytotoxic activity against blast cells[1][2].
In Vitro: Kevetrin hydrochloride (85, 170, 340 µM; 6 h) significantly inhibits KASUMI-1 cells growth in a dose-dependent manner, without affecting MOLM-13 cells[1].
Kevetrin hydrochloride (340 µM; 6 h) induces metallothionein (MT) expression in acute myeloid leukemia (AML) cells, and also down-regulates genes in relation to p53 activity, the regulator of WNT/β-catenin signaling forkhead box K2 and the transcription factor signal transducer and activator of transcription 5A (STAT5A)[1].
Kevetrin hydrochloride (340 µM; 24 h) induces apoptosis on KASUMI-1 cell line, without leading cell cycle alteration[1].
Kevetrin hydrochloride (100, 200, 400 µM; 48 h) increases the mRNA and protein level of p53 and induces p21 protein production in A2780 cells[1].
In Vivo: Kevetrin hydrochloride (150-200 mg/kg; i.p.; 20 d) induces ~40% cell death in OV-90 or OVCAR-3 xenograft tumors, also inhibits tumor growth and extents survival time of mice with tumor xenograft mode[2].
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