Cefadroxil (hydrate)

Cefadroxil hydrate is an orally active broad-spectrum cephalosporin antibiotic. Cefadroxil hydrate inhibits bacterial cell wall synthesis and enhances the expression of glutamate transporter-1. Cefadroxil hydrate is dependent on the intestinal peptide transporter PepT1 for small intestinal absorption. Cefadroxil hydrate has inhibitory and bactericidal activity against a variety of Gram-positive and Gram-negative bacteria and has analgesic effects on neuropathic pain^{[1][2][3][4][5][6][7]}. IC50 & Target:Bacterial^[1][2] In Vitro:Cefadroxil hydrate has similar inhibitory activity against most Gram-positive and Gram-negative bacteria as Cephalexin and Cephradine (HY-B1156), but is twice as active as Cephalexin (HY-B0200) against Streptococcus pyogenes^[2].
In Vivo:Cefadroxil (25-200 mg/kg; p.o.) hydrate attains peak blood concentrations similar to Cephalexin at 25 and 100 mg/kg^[1].
Cefadroxil (150 mg/kg; p.o.) hydrate exerts analgesic effects on mechanical allodynia in rats and mice with spared nerve injury (SNI) model, and also shows analgesic effect on cold pain in mice^[4].
Cefadroxil (0.39-100 mg/kg; p.o.; single dose or three times at 24, 27, and 30 h) hydrate is more effective than Cephalexin in the rat streptococcal pneumonia model, with a larger AUC in lung tissue and a longer half-life^[6].