CL 218872
CAS No. : 66548-69-4
| Size | Price | Stock |
|---|---|---|
| 5mg | $35 | In-stock |
| 10mg | $50 | In-stock |
| 25mg | $105 | In-stock |
| 50mg | $180 | In-stock |
| 100mg | $300 | In-stock |
| 200 mg | Get quote | |
| 500 mg | Get quote | |
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| Cat. No. : | HY-103505 |
| M.Wt: | 278.24 |
| Formula: | C13H9F3N4 |
| Purity: | >98 % |
| Solubility: | DMSO : 16.67 mg/mL (ultrasonic;warming;heat to 60°C) |
CL 218872 is an orally active and selective ligand for the benzodiazepine receptor subtype BZ1. CL 218872 exhibits anxiolytic, sedative and anticonvulsant activities. CL 218872 can be used in researches of anxiety related disorders and epilepsy[1][2][3][4][5].
In Vivo:CL 218872 (ED50 of 58 mg/kg; p.o.) inhibits footshock-induced fighting in mice with 50-fold lower potency than Diazepam[2].
CL 218872 (5-20 mg/kg; p.o.) reduces locomotor activity, head-dipping, and rearing in rats, with sedative effects reversed by Flumazenil (HY-B0009)[3].
CL 218872 (20-40 mg/kg; s.c.) antagonizes Diazepam-induced loss of righting reflex in mice[4].
CL 218872 (5-20 mg/kg; i.p.) impairs place learning in rats, increasing swim path length and reducing quadrant bias in probe trials[5].
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