Propacetamol (hydrochloride)
CAS No. : 66532-86-3
Price and Availability of
CAS No. : 66532-86-3
| Size | Price | Stock |
|---|---|---|
| 5mg | $25 | In-stock |
| 10mg | $35 | In-stock |
| 50mg | $50 | In-stock |
| 100mg | $60 | In-stock |
| 200 mg | Get quote | |
| 500 mg | Get quote | |
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| Cat. No. : | HY-108292 |
| M.Wt: | 300.79 |
| Formula: | C14H21ClN2O3 |
| Purity: | >98 % |
| Solubility: | DMSO : 25 mg/mL (ultrasonic;warming;heat to 80°C);H2O : 250 mg/mL (ultrasonic) |
Introduction of
66532-86-3
:
Propacetamol (1200-1400 mg/kg; i.p.; single dose) induces acute lethal liver injury in BALB/c mice, with 1400 mg/kg causing 100% mortality by 168 h and 1200 mg/kg reducing survival to 10% over the same period[3].
Propacetamol (1200-1800 mg/kg; i.p.; single dose) induces acute liver injury in C57BL/6 mice with strain-specific tolerance, with 1600 and 1800 mg/kg causing 100% mortality by 168 h and 1200 mg/kg reducing survival to 50% over the same period[3].
Propacetamol (200 mg/kg; i.p.; single dose) produces significant antinociception in mice with acetic acid-induced persistent visceral pain, as measured by reduced abdominal writhing responses[4].
Propacetamol (270-540 mg/kg; i.p.; single dose) does not produce significant antinociception in female mice tested with the hot plate acute thermal pain assay[4].
Propacetamol (125-500 mg/kg; i.g.; single dose; 30 min before ASA) exerts a dose-dependent gastroprotective effect against ASA-induced gastric ulceration in male Wistar rats, with the 500 mg/kg dose reducing ulcer area by 52.9% and gastric mucosal MDA levels by 66.9%, and supporting adaptive antioxidant responses via maintenance of elevated gastric UA and glutathione levels[5].
Propacetamol hydrochloride is an orally active prodrug of paracetamol and an inducer of acute liver injury models, with multiple properties including antinociception, antioxidation and gastroprotection. Propacetamol hydrochloride potentiates Tramadol and attenuates Aspirin (HY-14654)-induced gastric mucosal damage and lipid peroxidation. Under specific conditions, Propacetamol hydrochloride also acts as a hepatotoxic inducer, triggering acute liver injury, oxidative stress and apoptosis, with strain differences in toxicity sensitivity. Propacetamol hydrochloride can be used in the research of acute liver injury, drug-induced hepatotoxicity and gastric mucosal damage[1][2][3][4][5].
In Vitro:Propacetamol induces acute liver injury through the following mechanisms: it is metabolized by CYP2E1 to form the toxic intermediate N-acetyl-p-benzoquinone imine (NAPQI), which depletes hepatic GSH and triggers oxidative stress, inflammatory responses and apoptosis; it also inhibits UGT1A1 expression and activates the JNK/ERK pathway. Its core activity mimics the toxicological effects of acetaminophen overdose[1].
In Vivo:Propacetamol hydrochloride (600-1200 mg/kg; i.p.; single injection) induces severe acute liver injury in male BALB/cByJNarl mice at 600 mg/kg, while 1200 mg/kg is lethal, causing 100% mortality within 14 h[2].Propacetamol (1200-1400 mg/kg; i.p.; single dose) induces acute lethal liver injury in BALB/c mice, with 1400 mg/kg causing 100% mortality by 168 h and 1200 mg/kg reducing survival to 10% over the same period[3].
Propacetamol (1200-1800 mg/kg; i.p.; single dose) induces acute liver injury in C57BL/6 mice with strain-specific tolerance, with 1600 and 1800 mg/kg causing 100% mortality by 168 h and 1200 mg/kg reducing survival to 50% over the same period[3].
Propacetamol (200 mg/kg; i.p.; single dose) produces significant antinociception in mice with acetic acid-induced persistent visceral pain, as measured by reduced abdominal writhing responses[4].
Propacetamol (270-540 mg/kg; i.p.; single dose) does not produce significant antinociception in female mice tested with the hot plate acute thermal pain assay[4].
Propacetamol (125-500 mg/kg; i.g.; single dose; 30 min before ASA) exerts a dose-dependent gastroprotective effect against ASA-induced gastric ulceration in male Wistar rats, with the 500 mg/kg dose reducing ulcer area by 52.9% and gastric mucosal MDA levels by 66.9%, and supporting adaptive antioxidant responses via maintenance of elevated gastric UA and glutathione levels[5].
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- Propacetamol (hydrochloride)
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- HY-108292
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