Pamoic acid (disodium)
CAS No. : 6640-22-8
| Size | Price | Stock |
|---|---|---|
| 10g | $50 | In-stock |
| 25g | $90 | In-stock |
| 50g | $125 | In-stock |
| 100g | $175 | In-stock |
| 250g | $290 | In-stock |
| 500g | $400 | In-stock |
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| Cat. No. : | HY-W010907 |
| M.Wt: | 432.34 |
| Formula: | C23H14Na2O6 |
| Purity: | >98 % |
| Solubility: | DMSO : 100 mg/mL (ultrasonic;warming;heat to 60°C) |
Pamoic acid disodium is a potent GPR35 agonist with an EC50 value of 79 nM. Pamoic acid disodium induces GPR35 internalization and activates ERK1/2 with EC50 values of 22 nM and 65 nM, respectively. Pamoic acid disodium potently recruits β-arrestin2 to GPR35 and has an antinociceptive effect[1].
IC50 & Target: EC50: 79 nM (GPR35), 65 nM (ERK1/2)[1]
In Vitro: Pamoic acid (0.1 nM-0.1 mM) induces GPR35a internalization with an EC50 value of 22 nM[1].
Pamoic acid (0-10 μM) induces ERK1/2 activation[1].
In Vivo: Pamoic acid disodium (0-100 mg/kg; s.c.; once) induces a dose-related antinociception in the abdominal constriction test[1].
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