NH2-PEG4-CH2CH2COOH
CAS No. : 663921-15-1
| Size | Price | Stock |
|---|---|---|
| 100mg | $14 | In-stock |
| 250mg | $19 | In-stock |
| 1g | $32 | In-stock |
| 5g | $134 | In-stock |
| 25g | $457 | In-stock |
| 100g | $1509 | In-stock |
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| 500 g | Get quote | |
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| Cat. No. : | HY-W021787 |
| M.Wt: | 265.30 |
| Formula: | C11H23NO6 |
| Purity: | >98 % |
| Solubility: | DMSO : 10 mg/mL (ultrasonic;warming;heat to 60°C) |
NH2-PEG4-CH2CH2COOH is a cleavable 4 unit PEG ADC linker used in the synthesis of antibody-drug conjugates (ADCs). NH2-PEG4-CH2CH2COOH is also a PEG-based PROTAC linker that can be used in the synthesis of PROTACs.
In Vitro: ADCs are comprised of an antibody to which is attached an ADC cytotoxin through an ADC linker.
PROTACs contain two different ligands connected by a linker; one is a ligand for an E3 ubiquitin ligase and the other is for the target protein. PROTACs exploit the intracellular ubiquitin-proteasome system to selectively degrade target proteins.
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