5'-Deoxy-5-fluorocytidine
CAS No. : 66335-38-4
(Synonyms: 5-Fluoro-5'-deoxycytidine)
| Size | Price | Stock |
|---|---|---|
| 5g | $12 | In-stock |
| 25g | $52 | In-stock |
| 100g | $167 | In-stock |
| 500g | $706 | In-stock |
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| Cat. No. : | HY-W009538 |
| M.Wt: | 245.21 |
| Formula: | C9H12FN3O4 |
| Purity: | >98 % |
| Solubility: | DMSO : 100 mg/mL (ultrasonic) |
5'-Deoxy-5-fluorocytidine (5-Fluoro-5'-deoxycytidine) is a cytidine analog and metabolite of Capecitabine (HY-B0016). 5'-Deoxy-5-fluorocytidine is converted from Capecitabine by carboxylesterase in the liver. 5'-Deoxy-5-fluorocytidine is deaminated by cytidine deaminase to generate 5'-deoxy-5-fluorouridine, which is finally converted into 5-fluorouracil (HY-90006) by thymidine phosphorylase in tumor tissues to exert anti-tumor effects. 5'-Deoxy-5-fluorocytidine is used in the researches for solid tumors such as colorectal cancer, non-small cell lung cancer and breast cancer[1][2][3][4]. In Vitro:5'-Deoxy-5-fluorocytidine (200 μM) significantly inhibits the proliferation of chemotherapy-resistant A549 paraclone cells[4].
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