Ibuprofen guaiacol ester
CAS No. : 66332-77-2
(Synonyms: Methoxybutropate; AF 2259; Metoxibutropate)
| Size | Price | Stock |
|---|---|---|
| 1mg | $53 | In-stock |
| 5mg | $160 | In-stock |
| 10mg | $256 | In-stock |
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| Cat. No. : | HY-108308 |
| M.Wt: | 312.40 |
| Formula: | C20H24O3 |
| Purity: | >98 % |
| Solubility: | DMSO : 50 mg/mL (ultrasonic) |
Ibuprofen guaiacol ester (AF 2259; Metoxibutropate) is an orally active mutual prodrug of Ibuprofen (HY-78131) and Guaiacol (HY-N1380), designed to reduce the gastrointestinal (GI) side effects of ibuprofen. Ibuprofen guaiacol ester inhibits the synthesis of prostaglandin. Ibuprofen guaiacol ester inherits the antipyretic, analgesic and anti-inflammatory properties of Ibuprofen and Guaiacol, but reduces gastric damage. Ibuprofen guaiacol ester can be used to alleviate gastric erosion/ulcers induced by classic anti-inflammatory agent (such as Ibuprofen)[1][2].
In Vivo:Ibuprofen guaiacol ester (p.o.) effectively inhibits the synthesis of prostaglandins, while significantly reducing the typical gastric mucosal damage side effect of Ibuprofen in animal[1].
Ibuprofen guaiacol ester, at equimolar doses, is equally active to Ibuprofen on edema and fever without ulcerogenic and side effects (behavioral disorders and acute toxicity) in rats[2].
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