BN-82451 (dihydrochloride)
CAS No. : 663172-95-0
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| 1mg | $545 | Get quote |
| 5mg | $1353 | Get quote |
| 10mg | $1961 | Get quote |
| 50 mg | Get quote | |
| 100 mg | Get quote | |
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| Cat. No. : | HY-119274 |
| M.Wt: | 391.40 |
| Formula: | C18H28Cl2N2OS |
| Purity: | >98 % |
| Solubility: |
BN-82451 dihydrochloride, an orally active and CNS-penetrated antioxidant and a multitargeting neuroprotective agent, exert a significant protection in experimental animal models mimicking aspects of cerebral ischemia, Parkinson disease, Huntington disease, and more particularly amyotrophic lateral sclerosis[1][2].
In Vitro:BN82451 exhibits IC50 values of 0.08 and 0.05 µM for COX-1 and COX-2, respectively[2].
BN82451 acts via three major pathways involved in neuronal death: excitotoxicity, oxidative stress, and inflammation, and is also a mitochondrial protective agent[2].
BN82451 inhibits lipid peroxidation in rat brain microsomes in a concentration-dependent manner with an IC50 value of 0.54 µM[2].
In Vivo:BN-82451 improves motor ability and attenuates neurodegeneration in a mouse model of Huntington’s disease (HD)[1].
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Inquiry Information- Product Name:
- BN-82451 (dihydrochloride)
- Cat. No.:
- HY-119274
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