ML171
CAS No. : 6631-94-3
(Synonyms: 2-Acetylphenothiazine; 2-APT)
| Size | Price | Stock |
|---|---|---|
| 5g | $40 | In-stock |
| 25g | $151 | In-stock |
| 100g | $482 | In-stock |
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| 500 g | Get quote | |
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| Cat. No. : | HY-12805 |
| M.Wt: | 241.31 |
| Formula: | C14H11NOS |
| Purity: | >98 % |
| Solubility: | DMSO : ≥ 64 mg/mL |
ML171 (2-Acetylphenothiazine;2-APT) is a potent and selective NADPH oxidase 1 (Nox1) inhibitor that blocks Nox1-dependent ROS generation, with an IC50 of 0.25 μM in HEK293-Nox1 confirmatory assay. IC50 & Target: IC50: 0.25 μM (HEK293-Nox1), 0.129 μM (HT29)[1] In Vitro: Nox1-dependent ROS generation has been shown to play a pivotal role in cell signaling, cell growth, angiogenesis, motility and blood pressure regulation. ML171 strongly blocks ROS generation in HT29 cells (IC50=0.129 μM) and only increasing over-expression of Nox1 can overcome the blockage of ROS generation caused by ML171 treatment in HEK293 cell system reconstituted with all the components required Nox1-dependent ROS generation. ML171 efficiently blocks ROS production measured by carboxy-H2-DCFDA staining as well as DPI used as a positive control. When ML171 is tested in HEK293-Nox1 reconstituted cell system, higher potency in blocking Nox1-dependent ROS generation is observed compared with the parental compound[1].
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