Cefotiam (hydrochloride)
CAS No. : 66309-69-1
(Synonyms: SCE-963 (hydrochloride))
| Size | Price | Stock |
|---|---|---|
| 5mg | $25 | In-stock |
| 10mg | $31 | In-stock |
| 25mg | $50 | In-stock |
| 50mg | $65 | In-stock |
| 100mg | $85 | In-stock |
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| Cat. No. : | HY-B0734A |
| M.Wt: | 598.55 |
| Formula: | C18H25Cl2N9O4S3 |
| Purity: | >98 % |
| Solubility: | H2O : 33.33 mg/mL (ultrasonic);DMSO : 100 mg/mL (ultrasonic) |
Cefotiam (SCE-963) hydrochloride is a parenteral cephalosporin antibiotic. Cefotiam hydrochloride has broad-spectrum activity against Gram-positive and Gram-negative bacteria[1][2].
In Vitro: Cefotiam (SCE-963; 0-6.25 μg/mL; 8 h) hydrochloride has antibacterial activity with a MIC value of 1.56 μg/mL for P. mirabilis IFO 3849[1].
Cefotiam (SCE-963; 0-6.25 μg/mL; 8 h) hydrochloride has highly active against both Staph. aureus (27 strains, MIC values of 0.5-1 μg/mL) and Staph. albus (8 strains, MICs 0.25-0.5 μg/mL). All 29 strains of haemolytic streptococci, 9 strains of pneumococci and 6 strains of Streptococcus viridans with the MIC values of in the range 0.06-4 μg/mL[2].
In Vivo: Cefotiam (SCE-963; 12.5-800 mg/kg; i.h.; twice a day for 5 d) hydrochloride can cure urinary tract infection with P. mirabilis in mice to reduce or complete eradicate bacteria in the bladder walls and kidneys[1].
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