Sancycline (hydrochloride)
CAS No. : 6625-20-3
(Synonyms: Bonomycin (hydrochloride); 6-Demethyl-6-deoxytetracycline (hydrochloride))
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| Cat. No. : | HY-17466A |
| M.Wt: | 450.87 |
| Formula: | C21H23ClN2O7 |
| Purity: | >98 % |
| Solubility: | 10 mM in DMSO |
Sancycline (6-Demethyl-6-deoxytetracycline) hydrochloride acts by reversibly binding to the 30 S ribosomal subunit and inhibiting protein translation by blocking entry of aminoacyl-tRNA into the ribosome a site similar to tetracycline (HY-A0107). Sancycline hydrochloride, four linearly fused six-membered rings with four stereocenters, is a rare semi-synthetic tetracycline (HY-A0107) prepared by hydrogenolysis of the chloro and benzylic hydroxy moieties of Declomycin[1][2][3].
In Vitro:Sancycline hydrochloride (400 μM, 24 h) decreases 2 chloroethyl ethyl sulfide (CEES) and nitrogen mustard (NM) induced corneal injuries and inhibits Matrix metalloproteinase (MMP)-9 expression to some degree in the basement membrane zone (BMZ) increased by NM[2].
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