Cyromazine

Cyromazine (CGA-72662) is a triazine insect growth regulator used as an insecticide and an acaricide. It is a cyclopropyl derivative of melamine. Cyromazine works by affecting the nervous system of the immature larval stages of certain insects. Cyromazine reduced the number of germ cells by interfering with the Ecdysone (HY-N0179) signaling pathway. Cyromazine induces renal toxicity attenuated and restored by green tea extract in rats^{[1][2][3][4][5]}. In Vivo:Cyromazine (50 PPM, feed on a diet for 3 days) may decrease the number of germline stem cells (GSCs) and cystoblasts (CBs) in the 3-day old female adult ovary by affecting the expression of Ecdysone (HY-N0179) signaling-related genes, leading to a decrease fecundity^[2].
Cyromazine (169.35 mg/kg, oral gavage for 28 consecutive days) combined with Chlorpyrifos (HY-B0815) treated rats show huddling, mild tremor and diarrhea few minutes after dosing, but no manifestation is observed following aqueous green tea (GT) extract supplementation^[3].
Cyromazine (169.35 mg/kg, oral gavage for 28 consecutive days) combined with Chlorpyrifos (HY-B0815) treated rats ameliorates the loss of body weight and the increase of relative kidney after the administration of aqueous green tea (GT) extract^[3].
Cyromazine (50 PPM, feed on a diet for 7 days) on the inhibition effect of primordial germ cells (PGCs) is through the Ecdysone (HY-N0179) signaling pathway in the germ cells of larval ovaries^[4].