Pergolide


CAS No. : 66104-22-1

(Synonyms: LY127809 (free base))

66104-22-1
Price and Availability of CAS No. : 66104-22-1
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10mg $84 In-stock
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Cat. No. : HY-13720
M.Wt: 314.49
Formula: C19H26N2S
Purity: >98 %
Solubility: DMSO : 4.17 mg/mL (ultrasonic;warming;heat to 60°C)
Introduction of 66104-22-1 :

Pergolide (LY127809 free base), an Ergoline derivative, is a potent and orally active dopamine D1 and D2 receptor agonist. Pergolide can be used for Parkinson's disease and hyperprolactinaemia research[1][2]. In Vitro:Pergolide (10 nM-50 μM) treatment dose-dependently inhibits H2O2-induced cell death in SH-SY5Y neuroblastoma cells, acting in very low concentrations (nanomolar range) and in very early stages of the neurotoxic intracellular process[2]. In Vivo:Pergolide (0.3 mg/kg; intraperitoneal injection; daily; 11 days) treatment reduces the number of working/reference memory errors a 6-OHDA-induced rat model of Parkinson's disease. Pergolide mesylate facilitates spatial memory and improves brain oxidative balance[3] .

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