Punicalagin
CAS No. : 65995-63-3
| Size | Price | Stock |
|---|---|---|
| 5mg | $55 | In-stock |
| 10mg | $99 | In-stock |
| 20mg | $165 | In-stock |
| 50mg | $330 | In-stock |
| 100mg | $528 | In-stock |
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| Cat. No. : | HY-N0063 |
| M.Wt: | 1084.72 |
| Formula: | C48H28O30 |
| Purity: | >98 % |
| Solubility: | DMSO : 50 mg/mL (ultrasonic);H2O : 100 mg/mL (ultrasonic) |
Punicalagin is a polyphenol ingredient isolated from Pomegranate (Punica granatum L.) or the leaves of Terminalia catappa L.. Punicalagin is a reversible and non-competitive 3CLpro inhibitor and inhibits SARS-CoV-2 replication in vitro. Punicalagin is an anti-hepatitis B virus (HBV) agent and has antioxidant, anti-inflammatory, and anticancer effects. Punicalagin has the potential for the research of COVID-19[1][2][3].
In Vitro: Punicalagin (100 mg/ml) induces apoptosis in HT-29, HCT116 colon cells[1].
Punicalagin slightly inhibits the PLpro activity with an IC50 of over 50 μM. Punicalagin inhibits the plaque formation of SARS-CoV-2 in a dose-dependent manner, with EC50 values of 7.20 μM[4].
Punicalagin binds at an allosteric site in the dimer interface. Punicalagin inhibit SARS-CoV-2 replication by a mechanism other than preventing S-mediated viral entry[4].
In Vivo: Punicalagin (10 mg/kg) inhibits the edema rate of 58.15% in rats[2].
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