DKM 2-93
CAS No. : 65836-72-8
| Size | Price | Stock |
|---|---|---|
| 50mg | $25 | In-stock |
| 100mg | $45 | In-stock |
| 250mg | $108 | In-stock |
| 500mg | $200 | In-stock |
| 1 g | Get quote | |
| 5 g | Get quote | |
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| Cat. No. : | HY-101836 |
| M.Wt: | 243.69 |
| Formula: | C11H14ClNO3 |
| Purity: | >98 % |
| Solubility: | DMSO : 125 mg/mL (ultrasonic) |
DKM 2-93 is a relatively selective inhibitor of UBA5 with an IC50 of 430 μM. IC50 & Target: IC50: 430 μM (UBA5), 90 μM (PaCa2 cells), 30 μM (Panc1 cells)[1] In Vitro: Ubiquitin-like modifier activating enzyme 5 (UBA5) is a novel pancreatic cancer therapeutic target. DKM 2-93 impairs pancreatic cancer cell survival through covalently modifying the catalytic cysteine of UBA5, thereby inhibiting its activity as a protein that activates the ubiquitin-like protein UFM1 to UFMylate proteins. DKM 2-93 inhibits PaCa2 and Panc1 cells survival with IC50s of 90 and 30 μM, respectively[1]. In Vivo: DKM 2-93 daily treatment significantly impairs tumor growth of PaCa2 cells in vivo in tumor xenograft studies in immune-deficient mice without causing any weight loss or overt toxicity[1].
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