Goserelin
CAS No. : 65807-02-5
(Synonyms: ICI 118630)
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| Cat. No. : | HY-13673 |
| M.Wt: | 1269.41 |
| Formula: | C59H84N18O14 |
| Purity: | >98 % |
| Solubility: | 10 mM in DMSO |
Goserelin (ICI 118630), a decapeptide analogue of gonadotropin-releasing hormone (GnRH/LHRH), functions as a GnRH agonist. Goserelin can be used for the research of breast cancer, epithelial ovarian cancer and prostate cancer[1][2].
IC50 & Target:GnRH[1]
In Vitro: Goserelin (1 nM-1 mM; 48-72 hours) promots EOC cell apoptosis[1].
Goserelin (100 μM; 24-72 hours) regulates the expression of human apoptosis-related genes in SKOV3-ip cells[1].
Goserelin (100 μM; 24-72 hours) influences EOC cell apoptosis by upregulating FOXO1 through the PI3K/AKT signaling pathway[1].
In Vivo: Goserelin (100 μg; s.c.; daily; for 19 days) significantly increases the proportion of apoptotic cells in the subcutaneous xenograft tumors[1].
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