AG1024
CAS No. : 65678-07-1
(Synonyms: Tyrphostin AG 1024)
| Size | Price | Stock |
|---|---|---|
| 5mg | $66 | In-stock |
| 10mg | $121 | In-stock |
| 50mg | $300 | In-stock |
| 100mg | $450 | In-stock |
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| Cat. No. : | HY-10253 |
| M.Wt: | 305.17 |
| Formula: | C14H13BrN2O |
| Purity: | >98 % |
| Solubility: | DMSO : ≥ 50 mg/mL |
AG1024 (Tyrphostin AG 1024) is a reversible, competitive and selective IGF-1R inhibitor with an IC50 of 7 μM. AG1024 inhibits phosphorylation of IR (IC50=57 μM). AG1024 induces apoptosis and has anti-cancer activity[1][2].
IC50 & Target: IC50: 7 μM (IGF1R) and 57 μM (IR)[1][2]
In Vitro: AG1024 (Tyrphostin AG 1024; 2-10 μM; 1-5 days) shows a dose-dependent inhibition of cell proliferation[1].
AG1024 (1-5 μM; 1-3 days) induces UT7-9 and Baf3-p210 cells apoptosis[1].
AG1024 (2 μM; 6, 12 hours) downregulates phospho-Akt, Bcr-Abl and upregulates DNA-PKcs[1].
In Vivo: AG1024 (Tyrphostin AG 1024; 30 μg; i.p.; per day; for 2 weeks) significantly delays the tumour growth[1].
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