2,3-Diaminophenazine
CAS No. : 655-86-7
(Synonyms: 2,3-Phenazinediamine; NNC39-0028)
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| Cat. No. : | HY-W020086 |
| M.Wt: | 210.24 |
| Formula: | C12H10N4 |
| Purity: | >98 % |
| Solubility: | DMSO : 5.83 mg/mL (ultrasonic) |
2,3-Diaminophenazine (2,3-Phenazinediamine) is an orally active amino derivative of phenazine. 2,3-Diaminophenazine can intercalate into DNA. 2,3-Diaminophenazine triggers photochemical reactions. 2,3-Diaminophenazine inhibits vascular hypertrophy and tissue AGE deposition in diabetic rats. 2,3-Diaminophenazine can be used for luminescence and diabetes research[1][2][3][4].
In Vitro:2,3-Diaminophenazine shows weak intercalative binding to double-stranded DNA with a binding constant Kb of 3.5 mM[3].
2,3-Diaminophenazine (13 μM) combined with visible light irradiation resulted in a 13-fold decrease in the lethal concentration 50 (LC50) in human skin fibroblasts (Hs-27) compared with dark conditions, indicating significant phototoxicity[3].
2,3-Diaminophenazine effectively inhibits the formation of AGEs with an IC50 range of 30-40 µM (HPLC and 14C-lysine method) or < 10 µM (ELISA method)[4].
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