Thozalinone


CAS No. : 655-05-0

655-05-0
Price and Availability of CAS No. : 655-05-0
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Cat. No. : HY-105856
M.Wt: 204.23
Formula: C11H12N2O2
Purity: >98 %
Solubility: DMSO : 25 mg/mL (ultrasonic)
Introduction of 655-05-0 :

Thozalinone is an orally active antidepressant agent. Thozalinone induces the release of Norepinephrine (HY-13715) and dopamine[1][2]. In Vivo:Thozalinone (2-64 mg/kg orally) shows hyperesthesia, alertness, and increased exploratory behavior in rats[1].
Thozalinone (30, 60, and 120 mg/kg orally) increases in motor activity in individual mice[1].
Thozalinone (2-64 mg/kg; i.p.) significantly prevents the depression caused by Tetrabenazine hexamate. All mice which are active demonstrated exploratory behavior by walking to theedge of the disk and looking over the side[1].

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