SK-216
CAS No. : 654080-03-2
| Size | Price | Stock |
|---|---|---|
| 5mg | $75 | In-stock |
| 10mg | $125 | In-stock |
| 25mg | $230 | In-stock |
| 50mg | $370 | In-stock |
| 100mg | $595 | In-stock |
| 200 mg | Get quote | |
| 500 mg | Get quote | |
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| Cat. No. : | HY-122714 |
| M.Wt: | 533.52 |
| Formula: | C29H29NNa2O6 |
| Purity: | >98 % |
| Solubility: | 10 mM in DMSO |
SK-216 is a plasminogen activator inhibitor-1 (PAI-1) inhibitor that acts as an anti-metastatic agent for human osteosarcoma and inhibits lung metastasis of human osteosarcoma[1].
In Vitro:SK-216 (0-50 μM, 48 h) can inhibit the invasion of 143B cells in a dose-dependent manner, but does not affect cell proliferation and migration[1].
In Vivo:SK-216 (i.p., 6.6 μg/200 μL in PBS, once every 3 days) inhibits lung metastasis of human osteosarcoma cells, but not tumor growth in primary tumors in male athymic nude mice with 143B-Luc cell model[1].
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