Cefetrizole
CAS No. : 65307-12-2
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| Cat. No. : | HY-U00266 |
| M.Wt: | 437.52 |
| Formula: | C16H15N5O4S3 |
| Purity: | >98 % |
| Solubility: | 10 mM in DMSO |
Ceftezole is an α-Glucosidase inhibitor with an IC50 and a Ki of 2.1 μM and 0.578 μM, respectively.
IC50 & Target: IC50: 2.1 μM (α-Glucosidase)[1]
Ki: 0.578 μM (α-Glucosidase)[1]
In Vitro: In in vitro α-Glucosidase assays, Ceftezole is shown to be a reversible, non-competitive inhibitor of yeast α-glucosidase with a Ki value of 5.78×10-7 M when the enzyme mixture is pretreated with ceftezole[1].
In Vivo: Using an in vivo streptozotocin-induced mouse model, blood glucose levels are confirmed to be decreased by 30% 20 min after Ceftezole treatment (10 mg/kg/day). Expression levels of glycogen synthase kinase-3, peroxisome proliferator-activated receptor-γ, and uncoupling protein-3 mRNA are also slightly decreased compare to controls following Ceftezole treatment[1].
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