Cefetamet pivoxyl

Cefetamet pivoxyl (Ro 15-8075 free base) is an orally active cephalosporin Antibiotic and a prodrug of Cefetamet (HY-A0111). After ingestion, Cefetamet pivoxyl is hydrolyzed by gastrointestinal esterases to form Cefetamet. Cefetamet pivoxyl is primarily active against aerobic Gram-negative bacteria (such as Enterobacteriaceae, *Neisseria*, *Haemophilus*) and some Gram-positive bacteria (such as non-enterococcal streptococci). Cefetamet pivoxyl exhibits potent in vivo antibacterial activity against strains of Gram-positive bacteria (S. pyogenes) and Gram-negative bacteria (E. coli, K. pneumoniae, S. marcescens, P. vulgaris, P. mirabilis, H. influenzae)^[1][2]. In Vitro:Cefetamet pivoxyl is primarily active against aerobic Gram-negative bacteria (e.g., Enterobacteriaceae, *Neisseria*, *Haemophilus*) and some Gram-positive bacteria (e.g., non-enterococcal streptococci)^[1]. In Vivo:Cefetamet pivoxyl (administered orally at 1 and 3 hours post-infection) exhibits potent in vivo antibacterial activity against Gram-positive (S. pyogenes) and Gram-negative (E. coli, K. pneumoniae, S. marcescens, P. vulgaris, P. mirabilis, H. influenzae) strains, but shows no significant activity against S. aureus^[2].