Isosorbide


CAS No. : 652-67-5

(Synonyms: D-Isosorbide; Dianhydro-D-glucitol)

652-67-5
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Cat. No. : HY-B1469
M.Wt: 146.14
Formula: C6H10O4
Purity: >98 %
Solubility: H2O : ≥ 100 mg/mL;DMSO : ≥ 100 mg/mL
Introduction of 652-67-5 :

Isosorbide (D-Isosorbide), an orally active vasodilating agent that can be used for the research of heart failure and angina (chest pain). Isosorbide is also an oral hyperosmotic diuretic[1][2]. In Vivo: Isosorbide (5 mg/kg; a single p.o.) significantly increases the urine volume of rats within 2 hours which lasts through the 8 hour experimental period[3].
Isosorbide (5 mg/kg; a single p.o. 30 min prior to gallium injection) significantly reduces the urinary concentrations of both gallium and calcium in rats[3].
Isosorbide (5 mg/kg; p.o. 30 min prior to gallium injection for 6 d) results in the formation of fewer renal precipitates and histopathologic changes than in the nondiuresed animals[3].

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