3,5,6-Trichloro-2-pyridinol
CAS No. : 6515-38-4
(Synonyms: TCPy)
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| 25g | $18 | In-stock |
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| Cat. No. : | HY-W018171 |
| M.Wt: | 198.43 |
| Formula: | C5H2Cl3NO |
| Purity: | >98 % |
| Solubility: | DMSO : 32.5 mg/mL (ultrasonic) |
3,5,6-Trichloro-2-pyridinol (TCPy) is a chloride of 2-pyridone with oral activity. 3,5,6-Trichloro-2-pyridinol is the main degradation product of the herbicide Triclopyr and the insecticides Chlorpyrifos and chlorpyrifos-methyl. 3,5,6-Trichloro-2-pyridinol is associated with attention deficit hyperactivity disorder (ADHD) and decreased testosterone levels. 3,5,6-Trichloro-2-pyridinol causes hearing loss, hepatotoxicity and nephrotoxicity in mice [1][2][3][4][5].
In Vivo:3,5,6-Trichloro-2-pyridinol (50-150 mg/kg, 21 days) can cause oxidative stress, inflammation, and imbalance of cochlear potential in the cochlea, induce cochlear DNA damage and apoptosis, and cause cochlear morphological changes, eventually leading to impaired hearing function[4].
3,5,6-Trichloro-2-pyridinol (5-150 mg/kg, daily for 28 days) induces hepatotoxicity and nephrotoxicity, as well as metabolic disturbances[5].
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