KCL-440
CAS No. : 651029-09-3
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| Cat. No. : | HY-15050 |
| M.Wt: | 294.35 |
| Formula: | C18H18N2O2 |
| Purity: | >98 % |
| Solubility: | 10 mM in DMSO |
KCL-440 is a CNS-penetrated PARP inhibitor, with an IC50 of 68 nM. KCL-440 has strong inhibition of PARP-1[1][2].
IC50 & Target: IC50: 68 nM (PARP)[1].
In Vivo: The brain concentration of KCL-440 is sufficient to inhibit the PARP activity during the intravenous infusion at the rate of 1 mg/kg/h[1].
KCL-440 (over 0.03 mg/kg/h) exhibits neuroprotective effects of KCL-440 in the in vivo cerebral ischemia model[1].
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- HY-15050
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