Orotic acid
CAS No. : 65-86-1
(Synonyms: 6-Carboxyuracil; Vitamin B13)
| Size | Price | Stock |
|---|---|---|
| 100g | $12 | In-stock |
| 500g | $53 | In-stock |
| 1000g | $105 | In-stock |
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| Cat. No. : | HY-N0157 |
| M.Wt: | 156.10 |
| Formula: | C5H4N2O4 |
| Purity: | >98 % |
| Solubility: | DMSO : 55 mg/mL (ultrasonic);H2O : < 0.1 mg/mL |
Orotic acid (6-Carboxyuracil), a precursor in biosynthesis of pyrimidine nucleotides and RNA, is released from the mitochondrial dihydroorotate dehydrogenase (DHODH) for conversion to UMP by the cytoplasmic UMP synthase enzyme. Orotic acid is a marker for measurement in routine newborn screening for urea cycle disorders. Orotic acid can induce hepatic steatosis and hepatomegaly in rats[1][2][3].
In Vitro: Orotic acid is found in milk and dairy products, and it is converted to uridine for use in the pyrimidine salvage pathway predominantly in liver, kidney and erythrocytes[2].
In Vivo: Orotic acid is a marker for measurement of urea cycle disorders (UCDs), including ornithine transcarbamylase deficiency (OTCD)[2].
Orotic acid (1.0% addition to the diet; p.o. for 3-10 d) induces a development of fatty liver by day 7, and decreases purine/pyrimidine ratio of hepatic acid-soluble nucleotides by day 3[3].
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