N-Acetyl-L-methionine

N-Acetyl-L-methionine is a dietary supplementation. N-Acetyl-L-methionine increases caspase-3 activity and inhibits mitochondrial activity. N-Acetyl-L-methionine promotes lactation and improves meat quality^{[1][2][3][4][5][6]}. In Vitro: N-Acetyl-L-methionine (75 μM) reduces the number of chemical modifications and structural changes of recombinant human serum albumin (rHSA) more effectively than N-Acetyl-L-tryptophan when rHSA is oxidized by chloramine-T^[2].
N-Acetyl-L-methionine (0-500 µg/mL; 24-72 h) inhibits the growth and mitochondrial activity of Jurkat cells and MTC-SK cells in a concentration- and time- dependent manner^[3].
In Vivo: N-Acetyl-L-methionine (i.v.) is superior in preserving the normal pharmacokinetics of indocyanine green-labeled rHSA in male mice compared to N-Acetyl-L-tryptophan^[2].
N-Acetyl-L-methionine (30 g/cow per d; p.o., diet; once daily; 21-d treatment periods with 4 periods in total) increases milk fat concentration and yield as well as 3.5% fat-corrected milk yield in lactating dairy cows^[4].
N-Acetyl-L-methionine (0.125%-0.50% of dry matter basis; added to the diet; once daily) improves meat quality by enhancing the antioxidant effect of lipids and proteins, with the optimal dose being 0.25% of dry matter basis in finishing Angus heifers^[5].
N-Acetyl-L-methionine (equimolar levels to L-methionine ranging from 0 to 5.0% in the diet; p.o.; ad libitum; 14 days) causes progressive decreases in weight gain of growing rats at levels higher than the beneficial level (0.3% supplemental L-methionine equivalent)^[6].