Have any questions? [email protected] +86-21-58998590
Structure search

Yohimbine (Hydrochloride)


CAS No. : 65-19-0

65-19-0
Price and Availability of CAS No. : 65-19-0
Size Price Stock
500mg $30 In-stock
1g $50 In-stock
5g $125 In-stock
10g $200 In-stock
50 g Get quote
100 g Get quote
We match the lowest price on market.

We offer a substantial discount on larger orders, please inquire via [email protected]

or Fax: (86)21-58955996

Inquiry for price and availability only. Please place your order via our email or fax.

Cat. No. : HY-N0127
M.Wt: 390.90
Formula: C21H27ClN2O3
Purity: >98 %
Solubility: DMSO : 33.33 mg/mL (ultrasonic);H2O : 3.33 mg/mL (ultrasonic)
Introduction of 65-19-0 :

Yohimbine hydrochloride is an alpha-2 renal adenomatase receptor inhibitor, blocking pre- and post-contact alpha-2 renal adenomatase receptors, causing the release of renal adenoma and multiple sclerosis. In Vivo:Yohimbine Hydrochloride can be used in animal modeling to create hypertension models. Administering yohimbine hydrochloride (0.2 mg/kg, intraperitoneally) to rats 1 hour before stress each day for 14 consecutive days, followed by immersing the rats in cold water, significantly reduces sexual arousal and libido, as evidenced by increased latency and intervals. Reduced mating activity can be confirmed by decreased levels of testosterone, luteinizing hormone (LH), and follicle-stimulating hormone (FSH), along with a decline in testicular cholesterol content in the rats. Treatment with yohimbine significantly enhances sexual arousal and performance and corrects the impact of stress on mating behavior in male rats[1].

Induction of hypertension[1].
Background
The responses to pressor nerve stimulation in the pithed rat are mediated by α1A-, α2A- and α1D-adrenoceptors. Yohimbine (Hydrochloride), in addition to has antagonist actions as an α2A-adrenoceptor antagonist, has antagonist actions at α1D- and α1A-adrenoceptors against pressor responses[1].
Specific Mmodeling Methods
Rats: Wistar• male• 2-3 month old• weighing 250-350 g[1]
Administration: 1 mg/kg• i.v.• a single dose for 5 min[1]
Rat: SHRs and WKY• male• 20-week-old• weighing 300-350 g[4]
Administration: 2 mg/kg• i.p.• daily for 2 weeks[4]
Note
(1) Rats were pithed and ventilated with 100% O2 at a stroke rate of 60 per min and volume of approximately 0.67 mL/100 g. The carotid artery was cannulated for measurement of blood pressure and drugs were injected into the jugular vein[1].
(2) Yohimbine (Hydrochloride) was dissolved in distilled water and dilutions made up in normal saline (NaCl 0.9%)[1].
(3) Before administration, animals were housed four per cage with free access to water and standard laboratory rat chow (Purina). The colony room had a temperature of 24±1°C, humidity of 45-55% and light/dark cycle (lights on 07:00-19:00)[4].
Modeling Indicators
Molecular changes: Yohimbine (Hydrochloride) produced a significant 3-fold shift in pressor potency of Amidephrine (HY-136474) and significantly shifted the pressor responses to phenylephrine[1].
Blood pressure change: Yohimbine (Hydrochloride) reduced significantly the heart rate in spontaneously hypertensive rats (SHRs)[4].
Pathological changes: Yohimbine (Hydrochloride) elicited a marked, significant increase in receptor density over the outer strip of the outer medulla[4].
Correlated Product(s): Methoxy-idazoxan; BMY 7378 (HY-100554); Prazosin (HY-B0193); RS 100329 (HY-116379); ARC 239 (HY-12709); SK&F 86466
Opposite Product(s): Amidephrine (HY-136474); Clonidine (HY-12721)

Your information is safe with us.