N-[3-(2-Furyl)acryloyl]-Phe-Gly-Gly
CAS No. : 64967-39-1
(Synonyms: FAPGG)
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| Cat. No. : | HY-W010991 |
| M.Wt: | 399.40 |
| Formula: | C20H21N3O6 |
| Purity: | >98 % |
| Solubility: | DMSO : 100 mg/mL (ultrasonic) |
N-[3-(2-Furyl)acryloyl]-Phe-Gly-Gly (FAPGG) is a specific substrate of angiotensin converting enzyme (ACE) with a Ki of 2.546×10-4 M. It is used as a chromogenic probe for quantitative detection of ACE activity. N-[3-(2-Furyl)acryloyl]-Phe-Gly-Gly can be hydrolyzed by ACE to generate N-[3-(2-furyl)acryloyl]-Phe (FAP) and Gly-Gly, and the ACE inhibitory effect is monitored by photometry. FAPGG competitively binds to the active center of ACE and is a key tool for screening ACE inhibitors such as Captopril (HY-B0368) and Dioscorin. Its reversible mechanism of action supports hypertension research and drug development targeting the renin-angiotensin system[1].
In Vitro:In the spectrophotometric ACE inhibition assay, N-[3-(2-Furyl)acryloyl]-Phe-Gly-Gly (FAPGG; 1×10-3-1×10-4 M; 5 min) is hydrolyzed by ACE with a Km of 2.546×10-4 M[1].
In the TLC-based ACE activity assay, N-[3-(2-Furyl)acryloyl]-Phe-Gly-Gly (FAPGG; 5×10-4 M; 10 min) reduces FAP production in the dioscorin-treated group, confirming its ACE inhibitory effect[1].
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