Pentoxifylline
CAS No. : 6493-05-6
(Synonyms: BL-191; PTX; Oxpentifylline)
| Size | Price | Stock |
|---|---|---|
| 500mg | $50 | In-stock |
| 1g | $60 | In-stock |
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| Cat. No. : | HY-B0715 |
| M.Wt: | 278.31 |
| Formula: | C13H18N4O3 |
| Purity: | >98 % |
| Solubility: | H2O : 93.3 mg/mL (ultrasonic;warming);DMSO : ≥ 2.8 mg/mL |
Pentoxifylline (BL-191), a haemorheological agent, is an orally active non-selective phosphodiesterase (PDE) inhibitor, with immune modulation, anti-inflammatory, hemorheological, anti-fibrinolytic and anti-proliferation effects. Pentoxifylline can be used for the research of peripheral vascular disease, cerebrovascular disease and a number of other conditions involving a defective regional microcirculation[1][2][3].
IC50 & Target:PDE[1]
In Vitro: Pentoxifylline (0.1-50 mM; 24-48 hours) inhibits cell proliferation in a dose-dependent manner[3].
Pentoxifylline (0.5 mM; 12-36 hours) increases apoptosis and decreases autophagy levels in MDA-MB-231 cells[3].
Pentoxifylline (0.5 mM; 12-36 hours) induces autophagy in MDA-MB-231 cells[3].
Pentoxifylline (0.5 mM; 24-48 hours) blocks cell cycle at the G0/G1 phase[3].
Pentoxifylline results in high LC3-II/LC3-ratio[3].
In Vivo: Pentoxifylline (200 mg/kg; i.p.) has a protective effect on rats with transient global ischemia and reduces cognitive impairment[4].
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