7α,25-Dihydroxycholesterol
CAS No. : 64907-22-8
(Synonyms: 7α,25-OHC)
| Size | Price | Stock |
|---|---|---|
| 1mg | $55 | In-stock |
| 5mg | $250 | In-stock |
| 10mg | $480 | In-stock |
| 25mg | $1060 | In-stock |
| 50mg | $1850 | In-stock |
| 100mg | $3250 | In-stock |
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| Cat. No. : | HY-113962 |
| M.Wt: | 418.65 |
| Formula: | C27H46O3 |
| Purity: | >98 % |
| Solubility: | DMSO : 4.55 mg/mL (ultrasonic);Ethanol : < 1 mg/mL |
7α, 25-dihydroxycholesterol (7α,25-OHC) is a potent and selective agonist and endogenous ligand of the orphan GPCR receptor EBI2 (GPR183). 7α, 25-dihydroxycholesterol is highly potent at activating EBI2 (EC50=140 pM; Kd=450 pM). 7α, 25-dihydroxycholesterol can serve as a chemokine directing migration of B cells, T cells and dendritic cells[1][2]. In Vitro:In vitro, 7α, 25-dihydroxycholesterol (7α,25-OHC) stimulates the migration of EBI2-expressing mouse B and T cells with half-maximum effective concentration values around 500 pM, but had no effect on EBI2-deficient cells[1]. In Vivo:EBI2-deficient B cells or normal B cells desensitized by 7α,25-Dihydroxycholesterol (1 μM; 1.5 hours) pre-treatment shows reduced homing to follicular areas of the spleen[1].
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