Atigliflozin
CAS No. : 647834-15-9
(Synonyms: AVE-2268)
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| Cat. No. : | HY-14810 |
| M.Wt: | 382.43 |
| Formula: | C18H22O7S |
| Purity: | >98 % |
| Solubility: | 10 mM in DMSO |
Atigliflozin (AVE-2268) is an orally active and selective SGLT-2 inhibitor, with IC50s of 10 nM and 8.2 μM for hSGLT-2 and hSGLT-1) respectively. Atigliflozin can lower the blood glucose and improve the impaired oral glucose tolerance. Atigliflozin can be used for research of type II diabetes mellitus[1].
In Vivo:AVE2268 (1-300 mg/kg, p.o.) causes a dose-dependent increase of urinary glucose excretion (UGE) in mice and rats[2].
AVE2268 (10-100 mg/kg, p.o.) dose-dependently decreases blood glucose excursions after glucose (i.p. or p.o.) administration in mice[2].
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