UTL-5g
CAS No. : 646530-37-2
(Synonyms: GBL-5g)
| Size | Price | Stock |
|---|---|---|
| 5mg | $130 | In-stock |
| 10mg | $200 | In-stock |
| 25mg | $406 | In-stock |
| 50mg | $575 | In-stock |
| 100mg | $815 | In-stock |
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| Cat. No. : | HY-117082 |
| M.Wt: | 271.10 |
| Formula: | C11H8Cl2N2O2 |
| Purity: | >98 % |
| Solubility: | DMSO : 100 mg/mL (ultrasonic) |
UTL-5g (GBL-5g), an anti-inflammatory TNF-α inhibitor, has chemoprotective and liver radioprotective effects. UTL-5g lowers hepatotoxicity, nephrotoxicity, and myelotoxicity induced by Cisplatin through TNF-α inhibition among other factors[1][2].
In Vitro: RAW 264.7 macrophages are transfected with the respective reporter assay plasmids, pretreated with UTL-5g at 1, 10 or 50 µM for 60 min and then challenged with 100 ng/ml LPS. After a 16 h incubation, transcription factor activity is measured. Transcription factors that shows a UTL-5g dose-dependent decrease in activity in two experiments are categorized as being disrupted by UTL-5g.
In Vivo: UTL-5g (GBL-5g) lowers levels of TGF-β and TNF-α elevated by lung irradiation[1].
UTL-5g (60 mg/kg; p.o.; daily for 4 days) shows positive effects in increasing the survival rates and extending the survival times[3].
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