THIP
CAS No. : 64603-91-4
(Synonyms: Gaboxadol)
| Size | Price | Stock |
|---|---|---|
| 5mg | $32 | In-stock |
| 10mg | $50 | In-stock |
| 25mg | $90 | In-stock |
| 50mg | $145 | In-stock |
| 100mg | $230 | In-stock |
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| Cat. No. : | HY-10232 |
| M.Wt: | 140.14 |
| Formula: | C6H8N2O2 |
| Purity: | >98 % |
| Solubility: | H2O : 23.33 mg/mL (ultrasonic);DMSO : 50 mg/mL (ultrasonic;adjust pH to 3 with HCl) |
THIP (Gaboxadol) is a selective extrasynaptic GABAA receptors (eGABARs) agonist (with blood-brain barrier permeability), shows an EC50 value of 13 µM for δ-GABAAR. THIP induces strong tense GABAA-mediated currents in layer 2/3 neurons, but shows on effect on miniature IPSCs. THIP can be used in studies of sleep disorders[1][2][3].
In Vitro:THIP (1 µM; 5 s) induces a robust tonic GABAA-mediated current in layer 2/3 neurons[1].
THIP (1 µM; 1 s) shows no affect miniature IPSCs in layer 2/3 neurons[1].
In Vivo:THIP (Gaboxadol) (0.5, 5.0 mg/kg; p.o.; single) shws a good oral utilization, with Fa values of 110% and 83% for dosage of 0.5 and 5.0 mg/kg, respectively[2].
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